Joi Ito's Socialtext Workspace : Dave's Favorite Applications

Smultron a text editor ~~with a Lisp backend (no, not that one)~~ which has now replaced SubEthaEdit as my favorite editor (at least, for non-collaborative editing)
TouchStream LP (Dvorak) indispensible, and so much more efficient than mice or trackballs or trackpads; especially since I suffer from RSI
Privoxy HTTP/HTTPS filtering proxy - get rid of ads, cookies, some malicious Javascript
Quicksilver instead of LaunchBar
SubEthaEdit for most purposes -- handles TeX well, and has neato and useful Rendezvous collaborative editing; vim at the command line
Locator a very nice interface to the locate commandline tool
iTerm a nice terminal program; I use the CVS build to keep up with patches and improvements
Bibdesk a Cocoa frontend to BiBTeX, for managing my bibliography (I'm writing my dissertation ATM)
StickyBrain Stickies with search and categorization; not pretty but it works
MacReporter dockling RSS aggregator
NetNewsWire Lite basic RSS aggregator
ecto blogging tool, for painless blogging
MICE iRC simple, plugin-able IRC client
Proteus X pretty, stable multiprotocol chat client; doesn't do group chat, but everything else nice and seamless
VoodooPad Lite your own personal Wiki
Watson alas, bought out by Sun; on the upside, a free serial number is available
Fink for all my favorite open source tools
CVL Cocoa interface to CVS
VLC multi-platform, multi-codec video player
SSHKeyChain interface between OS X's keychain and the SSH public key system
GPGMail GPG plugin for Mail.app because crypto matters
WeatherPop some limitations, but very useful for keeping an eye on weather
MenuCalendarClock exactly what it says
MenuMeters system activity monitor in the menubar
AudioScrobbler tracks your playlist, and publishes them; makes connections with other users who have similar tastes in music
Unicode Checker also adds a Unicode to/from HTML entities service
TypePad not strictly an app, but I like it
MacOS X Hints again, not an app, but indispensible for getting the most out of your Mac